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目的探讨老年2型糖尿病(T2DM)患者血浆同型半胱氨酸(Hcy)水平的变化。方法126例老年(年龄>65岁)T2DM患者为T2DM组,选择同期就诊的30例健康体检者为对照组,测定两组血糖、血脂和Hcy水平;采用彩色多普勒超声对T2DM患者下肢血管病变进行诊断。结果T2DM组Hcy为(9.6±2.5)μmol/L,明显高于对照组的(5.4±1.6)μmol/L(P<0.05);有血管病变(59例)的T2DM患者Hcy水平为(10.8±3.6)μmol/L,明显高于(67例)无血管病变患者的(8.6±2.5)μmol/L(P<0.05)。Spearman相关性分析显示,T2DM患者血浆Hcy水平与血管病变程度呈明显的正相关(r=6.43,P<0.05)。结论血浆Hcy水平与T2DM血管病变的发生明显相关,其机制可能与糖尿病性血管内皮损伤有关。
Objective To investigate the changes of plasma homocysteine (Hcy) level in elderly patients with type 2 diabetes mellitus (T2DM). Methods Twenty-six elderly T2DM patients (aged> 65 years old) underwent T2DM. Thirty healthy controls were selected as the control group, and the levels of blood glucose, blood lipids and Hcy were measured in the two groups. Color Doppler ultrasound Lesions are diagnosed. Results Hcy in T2DM group was (9.6 ± 2.5) μmol / L, significantly higher than that in control group (5.4 ± 1.6) μmol / L (P <0.05). The Hcy level in T2DM patients with vascular disease (59 cases) 3.6 μmol / L, which was significantly higher than that of 67 patients without angiopathy (8.6 ± 2.5) μmol / L (P <0.05). Spearman correlation analysis showed that there was a significant positive correlation between the level of Hcy and the degree of vascular lesion in T2DM patients (r = 6.43, P <0.05). Conclusions Plasma Hcy levels are significantly correlated with the occurrence of T2DM vascular lesions. The mechanism may be related to diabetic vascular endothelial injury.