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使用大鼠离体作功心脏缺血一再灌注损伤模型,观察心肌内游离氨基酸含量的变化以及牛磺酸(Taurine,Tau)对心脏的影响.发现再灌注损伤使心肌内所测17种游离氨基酸含量除Cys外部减少,其中Tau降低最显著.20 mmol·L~(-1)Tau能改善心脏的再灌注损伤,表现为:在再灌注期间促进心脏机械功能的恢复,减少室性心律失常的发生率,减少LDH与CK从心肌中漏出,减少脂质过氧化作用与钙的积聚以及减少心肌内游离氨基酸的丢失.提示:外源性Tau能够改善心脏的缺血一再灌注损伤.
A rat model of myocardial ischemia-reperfusion injury was used to observe the changes of myocardial free amino acids and the effects of Taurine (Tau) on the heart.It was found that the 17 kinds of free amino acids Tau decreased the most significantly except for the decrease of Cys. Twenty (20 mmol·L -1) Tau improved cardiac reperfusion injury by promoting the recovery of cardiac mechanical function and reducing ventricular arrhythmia during reperfusion Reduce the leakage of LDH and CK from the myocardium, reduce the lipid peroxidation and calcium accumulation, and reduce the loss of myocardial free amino acids.It is suggested that exogenous Tau can improve the ischemia-reperfusion injury in the heart.