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目的 通过 82例原发性肾病综合征 (Nephtoticsyndrome ,NS)病理与临床观察 ,分析探讨 2 4小时尿蛋白排出量和血肌酐与合并肾小管间质损害的关系。方法 将患者分A组 (无合并肾小管间质损害 ,n =33)和B组 (合并肾小管间质损害 ,n =4 9)进行对比分析。结果 NS时肾小管间质病变的发病率相当高 (4 9/82 ;5 9 76 % ) ,B组 2 4小时尿蛋白排出量明显高于A组 (P <0 0 5 ) ,两组血肌酐值差别无显著性意义 (P >0 0 5 )。结论 大量蛋白尿是NS的最主要临床特征 ,但其除作为一种肾脏损害标志外 ,更是一种促进肾病进展的独立危险因子 ,提示大量尿蛋白对肾小管间质的损害作用
Objective To investigate the relationship between 24-hour urinary protein excretion, serum creatinine and tubulointerstitial damage in 82 patients with primary nephritical syndrome (NS). Methods The patients were divided into group A (without tubulointerstitial lesions, n = 33) and group B (with tubulointerstitial lesions, n = 49) for comparative analysis. Results The incidence of tubulointerstitial lesions was very high in NS (49/82; 59 76%). The urinary protein excretion in 24 hours in group B was significantly higher than that in group A (P <0.05) There was no significant difference in creatinine (P> 0.05). Conclusions Massive proteinuria is the most important clinical feature of NS. However, it is an independent risk factor for nephropathy in addition to being a marker of renal damage, suggesting a role of large amounts of urinary protein in tubulointerstitial damage