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【目的】探讨糖耐量正常的肥胖青年男性过氧化氢（H2 O2）、总体抗氧化能力（T-Aoc）、25羟基维生素D3[25（O H ）D3]水平及其与胰岛素抵抗的关系。【方法】选取86名20～45岁糖耐量正常的青年男性为研究对象，其中体质量指数（BM I）≥25 kg/m2为肥胖组（44名），BM I＜25 kg/m2（42名）为对照组，分别测定H2O2、T-Aoc、25（OH）D3等指标水平。以胰岛素抵抗指数（Homa-IR）为因变量，行多元线性回归分析胰岛素抵抗的危险因素。【结果】肥胖组舒张压（DBP）、三酰甘油（TG）、空腹胰岛素（FINS）、糖负荷后2 h胰岛素（2hINS）、H2O2、Homa-IR高于对照组（ P ＜0．05），HDL、T-Aoc、25（OH）D3低于对照组（ P ＜0．05）。 T-AOC与BMI（ r ＝-0．321）、DBP（ r ＝-0．330）、Homa-IR（ r ＝-0．342）呈负相关（ P ＜0．05），与 HDL（ r＝0．484）、25（OH）D3（ r ＝0．312）呈正相关（ P＜0．05）。H2 O2与BMI（ r ＝0．302）、Homa-IR（ r＝0．381）呈正相关（ P ＜0．05）。多元线性回归分析显示，25（OH）D3、T-Aoc与 Homa-IR相关性最强。【结论】糖耐量正常的肥胖青年男性已发生血脂、血压代谢紊乱、胰岛素抵抗、维生素D水平下降及氧化应激增强，且氧化应激及维生素D是胰岛素抵抗的重要危险因素。“,”[Objective] To observe the levels of hydrogen peroxide (H2 O2 ) ,total antioxidant ability (T-Aoc) and 25(OH)D3 in obese neb with normal glucose tolerance(NGT) and its relationship with insulin resist-ance .[Methods] Totally 86 young men(aged 20~45 years old) with NGT were enrolled in the study ,and di-vided into obese group( n=44 ,BMI≥25kg/m2 ) and normal control group( n=42 ,BMI<25kg/m2 ) .H2 O2 , T-Aoc and 25(OH)D3 were measured .The risk factors of insulin resistance with insulin resistance index (Ho-ma-IR) as dependent variable were analyzed by using multiple linear regression .[Results] Diastolic blood pressure(DBP) ,triglyceride(TG) ,Fasting insulin(FINS) ,insulin after 2h-sugar load(2hINS) ,H2O2 and Homa-IR in obese group were higher than those in control group ( P <0 .05) ,while high density lipoprotein (HDL) ,T-Aoc and 25(OH)D3 were lower than those in control group( P<0 .05) .T-Aoc showed a negative correlation with BMI( r = -0 .321) ,DBP( r = -0 .330) and Homa-IR( r = -0 .342)( P < 0 .05) ,and a positivecorrelationwithHDL(r =0.484)and25(OH)D3(r =0.312)(P <0.05).H2O2 showedapositive correlation with BMI( r =0 .302) and Homa-IR( r =0 .381)( P <0 .05) .Multiple linear regression showed that the correlation of 25(OH)D3 and T-AOC with Homa-IR was the strongest .[Conclusion] Obese young men with NGT have the metabolic disorder of blood lipid and blood pressure ,insulin resistance ,vitamin D de-creasing and oxidative stress increasing .Oxidative stress and vitamin D are the important risk factors of insulin resistance .