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胆囊收缩素(CCK)在胃肠道的主要靶器官是胰和胆囊,但其受体却分布于整个胃肠道,其生理作用不仅在于刺激胰液和胆汁分泌,而且也调节胃肠动力。loxiglumide(L)系有效且高度特异的CCK拮抗剂,其作用机理在于能竞争性地与CCK的细胞膜受体相结合,本文旨在评价其在阻断CCK受体对胆囊收缩、胃排空和小肠、结肠转运时间的影响。健康男性志愿者37人(21～29岁),无服药史及胃肠道和内分泌疾病和手术史。胆囊收缩功能(n=5):超声扫描测定,以胆囊纵径、横径和前后径计算胆囊容积。实验共2次,一次
Cholecystokinin (CCK) in the gastrointestinal tract is the main target organ of the pancreas and gallbladder, but its receptors are distributed throughout the gastrointestinal tract, its physiological role not only in stimulating pancreatic juice and bile secretion, but also regulate gastrointestinal motility. Loxiglumide (L) is a potent and highly specific CCK antagonist whose mechanism of action is to competitively bind to the CCK receptor. This paper aims to evaluate the effect of CCK receptor antagonist on CCK, gastric emptying and Small intestine, colon transit time. 37 healthy male volunteers (21-29 years old), no medication history and gastrointestinal and endocrine diseases and surgical history. Gallbladder systolic function (n = 5): Ultrasound scan to determine gallbladder volume based on longitudinal, transverse and anteroposterior diameters of the gallbladder. A total of 2 experiments, once