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目的:探讨KLK6蛋白及其mRNA在原发性乳腺癌组织中的表达和临床意义。方法:随机选取原发性乳腺癌患者88例并收集其术后标本,采用SABC免疫组化方法和RT-PCR技术,检测乳腺癌组织和正常乳腺组织中KLK6蛋白及其mRNA的表达。并分析其与原发性乳腺癌组织临床病理学特征之间的关系。结果:KLK6蛋白在原发性乳腺癌组织中的阳性表达率为78.40%(69/88),并与癌组织的临床病理学特征有关;发生淋巴结转移及ER(+)的癌组织中KLK6蛋白的阳性表达率明显低于未转移组(P<0.05)及ER(-)组(P<0.05)。KLK6 mRNA在原发性乳腺癌组织中的表达水平显著高于正常乳腺组织(P<0.01);但发生淋巴结转移的癌组织中,KLK6 mRNA的表达水平明显低于未转移组(P<0.05);ER+组亦低于ER(-)组(P<0.05)。KLK6蛋白及其mRNA的表达与乳腺癌相关基因CerbB-2的表达无相关性(P>0.05)。结论:KLK6蛋白及其mRNA的异常表达可能与原发性乳腺癌的发生、浸润、转移有关,可以作为一个肿瘤标志物在临床中应用。
Objective: To investigate the expression of KLK6 protein and its mRNA in primary breast cancer and its clinical significance. Methods: 88 cases of primary breast cancer were randomly selected and their postoperative specimens were collected. The expression of KLK6 protein and its mRNA in breast cancer tissues and normal breast tissues were detected by SABC immunohistochemistry and RT-PCR. And analyze its relationship with clinicopathological features of primary breast cancer. Results: The positive rate of KLK6 protein in primary breast cancer tissues was 78.40% (69/88), which was correlated with the clinicopathological features of cancerous tissues. The expression of KLK6 protein in cancerous tissues with lymph node metastasis and ER (+) (P <0.05) and ER (-) group (P <0.05). The expression of KLK6 mRNA in primary breast cancer tissues was significantly higher than that in normal breast tissues (P <0.01). However, the expression of KLK6 mRNA in lymph node metastasis was significantly lower than that in non-metastasis group (P <0.05) ; ER + group was also lower than ER (-) group (P <0.05). The expression of KLK6 protein and its mRNA had no correlation with the expression of CerbB-2 in breast cancer (P> 0.05). Conclusion: The aberrant expression of KLK6 protein and its mRNA may be related to the occurrence, invasion and metastasis of primary breast cancer and may be used as a tumor marker in clinic.