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应用ABC免疫组化染色法对54例直肠癌、5例直肠息肉检测P53蛋白的表达。结果显示直肠癌中P53蛋白阳性率为48．15％（26／54），直肠息肉均为阴性。直肠癌P53蛋白阳性与Dukes分期无关，粘液低分化腺癌P53蛋白表达明显多于中分化腺癌（P＜0．05）。获随访30例中P53蛋白阳性者死亡率也显著增高（P＜0．01），提示直肠癌P53蛋白的异常表达可作为判断预后的一项指标。此外，研究肿瘤细胞的P53密度还可预测化疗敏感性，有助于术后辅助治疗方式的选择。
The expression of P53 protein was detected in 54 cases of rectal cancer and 5 cases of rectal polyps using ABC immunohistochemical staining. The results showed that the positive rate of P53 protein in rectal cancer was 48.15% (26/54), and rectal polyps were negative. The positive expression of P53 protein in rectal cancer was not related to Dukes stage. The expression of P53 protein in mucinous poorly differentiated adenocarcinoma was significantly more than that in moderately differentiated adenocarcinoma (P<0.05). The mortality rate of P53 protein positive in 30 cases was also significantly increased (P<0.01), suggesting that abnormal expression of P53 protein in rectal cancer can be used as an index to predict prognosis. In addition, the study of the density of P53 in tumor cells can also predict the sensitivity of chemotherapy, which is helpful for the choice of postoperative adjuvant therapy.