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目的研究凋亡抑制因子survivin在早期宫颈癌组织中的表达和意义。方法用免疫组织化学链霉菌抗生物素蛋白-过氧化酶连接法(SP法)检测53例早期宫颈癌(ICC)和10例癌旁正常宫颈上皮(NEC)中survivin表达情况。结果(1)宫颈癌组织survivin阳性表达率67.9%。在癌旁正常宫颈组织未发现阳性表达。(2)survivin的表达与年龄、FIGO分期、病理分级、淋巴结转移、术前治疗及预后密切相关(P<0.05),与组织学类型无相关性(P>0.05)。结论survivin可能在宫颈癌的发生发展过程中起关键作用,检测其表达水平,对于宫颈癌的诊断、恶性程度及预后的判断有一定价值。
Objective To study the expression and significance of survivin in early cervical cancer. Methods The expression of survivin in 53 cases of early cervical cancer (ICC) and 10 cases of normal cervical epithelium adjacent to cancer (NEC) was detected by immunohistochemical streptavidin-peroxidase (SP) method. Results (1) The positive rate of survivin in cervical cancer was 67.9%. No positive expression of normal cervical tissue adjacent to cancer. (2) The expression of survivin was closely related to age, FIGO stage, pathological grade, lymph node metastasis, preoperative treatment and prognosis (P <0.05), but not to the histological type (P> 0.05). Conclusion Survivin may play a key role in the development of cervical cancer. To detect the expression level of survivin may be of value in the diagnosis, malignancy and prognosis of cervical cancer.