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帕金森病是常见的神经退行性疾病之一。本病的主要病理特征是黒质致密部多巴胺能神经元变性、缺失,而且这种细胞死亡形式是以凋亡为主。抗凋亡已成为治疗帕金森病的又一策略。本文主要对能通过抑制帕金森病黑质多巴胺能神经元凋亡而产生的神经保护作用的药物做以综述。
Parkinson’s disease is one of the common neurodegenerative diseases. The main pathological features of this disease are the degeneration and loss of dopaminergic neurons in the substantia nigra pars compacta, and this form of cell death is predominated by apoptosis. Anti-apoptotic has become another strategy for the treatment of Parkinson’s disease. This review focuses on therapies that can protect neuroprotection by inhibiting the apoptosis of dopaminergic neurons in the substantia nigra of Parkinson’s disease.