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目的回顾性分析2008年-2012年间保定地区新生儿先天性甲状腺功能低下症(CH)的筛查情况及发病特征。方法以保定市区及各县出生的新生儿为筛查对象,采用时间分辨荧光分析法,测定新生儿足跟血干血斑中促甲状腺激素(TSH)的含量;结合血清学甲功结果综合诊断;并通过统计分析,了解该病的分布特征。结果 2008年-2012年共分娩活产儿744 983人,筛查新生儿504 642例,筛查覆盖率67.74%,确诊CH226例,CH发病率1/2233(44.78/10万),其中男121例,女105例,男女比例约为1.2∶1,筛查量和确诊量逐年递增,发病特点呈散发性分布。结论 1.随着人们对新生儿筛查认知度的提高,筛查量逐年递增。2.新生儿CH筛查是临床早发现该病的重要手段,为早诊断,早治疗,避免患儿体格和智能发育障碍提供科学依据。3.未发现家族性甲低发病。
Objective To retrospectively analyze the screening status and incidence of neonatal congenital hypothyroidism (CH) in Baoding from 2008 to 2012. Methods Newborn infants born in Baoding city and counties were screened for the levels of thyroid-stimulating hormone (TSH) in neonatal heel blood spots by time-resolved fluorescence analysis. The serum thyroid hormone Diagnosis; and through statistical analysis to understand the distribution characteristics of the disease. Results A total of 744 983 live births were observed during 2008-2012. 504 642 newborns were screened and screening coverage was 67.74%. Of the 226 confirmed CH22 cases, CH incidence was 1/2233 (44.78 / 100 000), of which 121 , Female 105 cases, male to female ratio of about 1.2: 1, screening and diagnosis increased year by year, the incidence of sporadic distribution characteristics. Conclusion 1. With the improvement of people’s awareness of newborn screening, the amount of screening increases year by year. Neonatal CH screening is an important means to early detection of the disease clinically, providing a scientific basis for early diagnosis and early treatment, to avoid physical and mental retardation in children. 3. No familial hypothyroidism was found.