论文部分内容阅读
目的:观察肾络通对梗阻性肾病模型大鼠肾组织血管活性物质的作用,为肾络通的临床应用提供实验依据。方法:健康雌性SD大鼠40只,随机分为假手术组(SHAM)、模型组(UUO)、缬沙坦治疗组(UUOV)、肾络通治疗组(UUOS),每组10只。观察各组动物病理学改变;放免法检测TXB2、6-keto-PGF1α、ET-1、NO的含量。结果:肾络通可减轻大鼠肾脏病理形态学的改变,降低TXB2、6-keto-PGF1α、ET-1、NO的含量。结论:肾络通可有效改善肾脏病理损伤,对梗阻性肾病模型大鼠有良好的治疗作用。
Objective: To observe the effect of Shenluotong on renal tissue vasoactive substances in rats with obstructive nephropathy model, and provide experimental evidence for the clinical application of Shenluotong. Methods: Forty healthy female Sprague-Dawley rats were randomly divided into sham-operated group (SHAM), model group (UUO), valsartan treatment group (UUOV) and renal collaterals treatment group (UUOS) The pathological changes of each group were observed. The levels of TXB2, 6-keto-PGF1α, ET-1 and NO were detected by radioimmunoassay. Results: Shenluotong can alleviate the pathological changes of rat kidney and decrease the contents of TXB2, 6-keto-PGF1α, ET-1 and NO. Conclusion: Shenluotong can effectively improve renal pathological injury and has a good therapeutic effect on rats with obstructive nephropathy.