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该文研究了十种苯丙氨酸(Phe)的对位衍生物Fp、Clp、Bp、Ip、Ap、Np、Sp、Mp、Pp、Cp对小鼠黑色素瘤细胞系B16的细胞毒性、诱导细胞凋亡作用和抑制细胞成集落作用。结果表明,它们的细胞毒性大小依次为Pp、Fp、Mp、Ip、Sp、Ap、Bp。其中Mp和Ip的毒性相近,Sp和Ap的毒性相近。它们诱导细胞凋亡的作用强弱依次为Fp、Mp、Ip。其中Mp和Ip的作用相近。它们抑制细胞成集落的作用大小依次为Pp、Fp、Ip、Mp、Sp、Bp、Np、Ap。其中Pp、Fp、Ip、Mp的作用相近,Sp、Bp、Np的作用相近。初步的细胞毒理分析表明,Fp、Mp、Ip能够诱导B16细胞凋亡和抑制B16细胞形成集落。
In this paper, the cytotoxicity and induction of ten phenylalanine (Phe) para-derivatives Fp, Clp, Bp, Ip, Ap, Np, Sp, Mp, Pp and Cp on murine melanoma cell line B16 Apoptosis and inhibition of cell colonization. The results showed that their cytotoxicity in order of Pp, Fp, Mp, Ip, Sp, Ap, Bp. Among them, Mp and Ip have similar toxicity, and Sp and Ap have similar toxicity. The induction of apoptosis in the role of the order of Fp, Mp, Ip. Which Mp and Ip similar role. Their inhibitory effect on cell colonization followed by the order of Pp, Fp, Ip, Mp, Sp, Bp, Np, Ap. The functions of Pp, Fp, Ip and Mp are similar, and the roles of Sp, Bp and Np are similar. Preliminary cytotoxic analysis showed that Fp, Mp, Ip could induce apoptosis of B16 cells and inhibit the formation of B16 cells.