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有报道表明,在相当数量的Hp感染者中发生了自身体液免疫反应。为了分析针对胃组织的自身抗体与Hp感染患者的组织学、血清学参数以及临床过程之间的关系,对126例上腹部不适患者进行了调查研究。 方法:每例患者通过活检以确定胃炎是否发生、严重程度及部位,是否存在肠化生及萎缩。胃炎按悉尼和ABC系统进行分类。以组织学和检测抗Hp抗体来确定是否存在Hp感染。以免疫组织化学法检查自身抗体。胃泌素浓度和胃蛋白酶原Ⅰ、Ⅱ的浓度利用放免试剂
It has been reported that there is a self humoral immune response in a significant number of Hp-infected persons. In order to analyze the relationship between histological, serological parameters and clinical course of autoantibodies against gastric tissue and Hp infection, 126 patients with upper abdominal discomfort were investigated. Methods: Each patient passed a biopsy to determine if gastritis occurred, its severity and location, and whether there was intestinal metaplasia and atrophy. Gastritis is classified by Sydney and ABC systems. Hp infection was determined by histology and detection of anti-Hp antibodies. Autoantibodies were examined by immunohistochemistry. Gastrin concentration and pepsinogen Ⅰ, Ⅱ concentration using radioimmunoassay