论文部分内容阅读
目的:研究阿奇霉素序贯疗法对小儿支原体肺炎患者炎性因子及体液免疫功能调节的影响。方法:选取2013年1月—2014年12月间诊治的小儿支原体肺炎患者100例作为研究对象;将其随机分为观察组和对照组,每组50例;对照组患者均给予阿奇霉素常规治疗,观察组患者均给予阿奇霉素序贯疗法治疗,治疗后检测两组患儿体内炎性因子(IL-10)、促炎因子(包括TNF-α、IFN-γ)以及体液免疫功能指标(包括免疫球蛋白Ig G、Ig A、Ig M和外周血中的补体C_3、C_4。结果:治疗前两组患儿血清中炎性因子均较高,经两组间比较其差异无统计学意义(P>0.05);治疗7和12 d时两组患儿血清中抗炎因子和促炎因子低于对照组(P<0.05);治疗前两组患儿外周血中Ig A水平处于较低水平,补体C_3、C_4以及Ig M、Ig G处于较高水平,经两组间比较其差异无统计学意义(P>0.05);治疗后两组患儿的Ig A水平上升,Ig M、Ig G下降,与治疗前比较其差异有统计学意义(P<0.05),且观察组患儿改善更加显著;观察组患儿补体C_3、C_4均显著下降;对照组患儿补体C3仍低于观察组(P<0.05),对照组患儿补体C_4与治疗前比较其差异无统计学意义(P>0.05)。结论:采用阿奇霉素序贯疗法治疗小儿支原体肺炎患儿,可显著改善其血清中炎性因子及体液免疫功能,其疗效优于阿奇霉素的常规治疗。
Objective: To study the effect of sequential therapy of azithromycin on inflammatory cytokines and humoral immune function in children with mycoplasma pneumonia. Methods: A total of 100 children with mycoplasma pneumonia who were diagnosed and treated between January 2013 and December 2014 were enrolled in this study. They were randomly divided into observation group and control group, 50 cases in each group. Patients in the control group were treated with azithromycin, The patients in observation group were treated with sequential therapy of azithromycin. After treatment, the levels of inflammatory cytokines (IL-10), proinflammatory cytokines (including TNF-α, IFN-γ) and humoral immune function indexes Protein Ig G, Ig A, Ig M and complement C_3, C_4 in peripheral blood.Results: The serum inflammatory cytokines in the two groups before treatment were higher than those in the two groups, but there was no significant difference between the two groups (P> 0.05). Serum levels of anti-inflammatory cytokines and proinflammatory cytokines in both groups were lower than those in the control group on the 7th and 12th day after treatment (P <0.05). Ig A levels in the peripheral blood of the two groups before treatment were at a low level, C_3, C_4 and Ig M and Ig G were in high level. There was no significant difference between the two groups after treatment (P> 0.05). After treatment, the levels of Ig A, Ig M and Ig G in the two groups increased, Compared with before treatment, the difference was statistically significant (P <0.05), and the observation group children improved more significantly; observation group children with complement C_3 (P <0.05), while there was no significant difference between the control group and the control group (P> 0.05) .Conclusion: The use of azithromycin sequential Treatment of children with children with mycoplasma pneumonia can significantly improve the serum inflammatory cytokines and humoral immune function, its efficacy is superior to the conventional treatment of azithromycin.