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我们应用血浆尿素氮、血浆肌酐、脑干电位、肾脏组织病理和耳蜗铺片观察庆大霉素引起的豚鼠肾功能和听功能改变，以及肾小管和耳蜗毛细胞的病理改变，发现用药期间，在出现耳毒作用之前先出现了肾毒作用，在出现耳毒作用时豚鼠表现为中医肾虚证候．实验证实肾功能的变化是耳中毒的先兆，提示临床上应用庆大霉素过程中，可以通过监测肾功能指标，若发现肾功能损害可以及早停药，可防止中毒性聋的发生；且发现实验结果与中医肾主耳理论相吻合，由此笔者提出庆大霉素中毒性聋中医肾虚假说，并探讨了肾毒性和耳毒性关系与中医肾虚的相关性．
We observed the changes of renal and auditory functions caused by gentamicin in guinea pigs and the pathological changes of tubular and cochlear hair cells using plasma urea nitrogen, plasma creatinine, brain stem potential, renal histopathology and cochlear implants. Before the emergence of ototoxicity nephrotoxic effect appeared in the role of ototoxicity in guinea pigs showed deficiency of TCM. Experiments confirmed that changes in renal function is a precursor to ototoxicity, suggesting that clinical application of gentamicin can monitor renal function indicators, if found renal dysfunction can be discontinued as early as possible to prevent the occurrence of toxic deafness; and found that The experimental results are in line with the theory of kidney Lord of the Chinese medicine, so I proposed gentamicin toxic deafness of Chinese medicine kidney falsehood, and explored the relationship between nephrotoxicity and ototoxicity and kidney deficiency.