论文部分内容阅读
目的探讨谷氨酰胺与2型糖尿病的关系。方法采用高效液相色谱仪(HPLC)来测定新疆维、哈两民族血浆中谷氨酰胺的含量;使用放免法测定空腹血清胰岛素(FINS)含量;采用全自动生化分析仪来测定空腹血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDLC)、低密度脂蛋白(LDLC)的含量。结果维吾尔族正常人与糖尿病患者之间血浆中谷氨酰胺含量差异有统计学意义(P<0.01);哈萨克族正常人与糖尿病患者之间血浆中谷氨酰胺含量差异无统计学意义;维哈两民族的正常人血浆中谷氨酰胺含量差异有统计学意义(P<0.01);维哈两民族的糖尿病患者血浆中谷氨酰胺的含量差异有统计学意义(P<0.05)。维哈两民族人群血浆中的谷氨酰胺含量与空腹血糖(FBG)水平呈负相关(r=-0.4858,P<0.001),与FINS水平呈正相关(r=0.236,P<0.05),与胰岛素分泌指数(HOMA-IS)呈正相关(r=0.52,P=0.001),与TG呈负相关(r=-0.4330,P<0.01),与LDLC呈负相关(r=-0.4077,P<0.01),与HDLC呈正相关(r=0.2553,P<0.01)。结论谷氨酰胺可能是2型糖尿病的一个保护性的影响因素。
Objective To investigate the relationship between glutamine and type 2 diabetes mellitus. Methods The content of glutamine in the plasma of the two ethnic groups in Victoria and Kazakhstan in Xinjiang was determined by high performance liquid chromatography (HPLC). The content of fasting serum insulin (FINS) was determined by radioimmunoassay. The levels of total cholesterol TC, TG, HDLC and LDLC were measured. Results There was a significant difference in plasma glutamine levels between Uygur normal subjects and diabetic subjects (P <0.01). There was no significant difference in plasma glutamine levels between Kazakh normal subjects and diabetic subjects. (P <0.01). There was significant difference in the plasma levels of glutamine among the two ethnic groups in Weijia (P <0.05). There was a negative correlation between plasma glutamine levels and fasting blood glucose (FBG) levels in two ethnic groups (r = -0.4858, P <0.001) and a positive correlation with FINS (r = 0.236, (R = -0.4330, P <0.01), but negatively correlated with LDLC (r = -0.4077, P <0.01) , Which was positively correlated with HDLC (r = 0.2553, P <0.01). Conclusion Glutamine may be a protective factor in type 2 diabetes mellitus.