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目的观察T2DM患者血清血管生成素2(Ang-2)水平,探讨其与糖尿病微血管病变的关系。方法将64例T2DM患者分为单纯糖尿病(T2DM)组28例及糖尿病慢性肾脏疾病(CKD)组36例,另选健康对照(NC)组23名,检测各组血清Ang-2水平。结果 CKD组Ang-2水平高于T2DM组(2.38 vs 1.12ng/ml,P<0.01),T2DM组Ang-2水平高于NC组(1.12 vs 0.46ng/ml,P<0.01)。增殖性DR患者Ang-2水平高于非增殖性DR患者(2.83 vs 1.96ng/ml,P<0.01),非增殖性DR患者Ang-2水平高于无DR患者(1.96 vs 1.08ng/ml,P<0.05)。Ang-2水平与高敏C反应蛋白(hsC-RP)(r=0.63,P<0.01)、UAlb(r=0.29,P<0.05)呈正相关。结论 T2DM患者血清Ang-2水平升高,与hsC-RP、UAlb、DR颈动脉内-中膜厚度均呈正相关,血清Ang-2水平可作为评价T2DM患者肾脏和视网膜微血管病变的指标。
Objective To observe the level of serum Angiopoietin 2 (Ang-2) in patients with T2DM and explore its relationship with diabetic microangiopathy. Methods Sixty-four patients with T2DM were divided into two groups: 28 cases in T2DM group and 36 cases in CKD group, and 23 cases in NC group. The level of serum Ang-2 in each group was detected. Results The Ang-2 level in CKD group was significantly higher than that in T2DM group (2.38 vs 1.12 ng / ml, P <0.01). The level of Ang-2 in T2DM group was significantly higher than that in NC group (1.12 vs 0.46 ng / ml, P <0.01). Ang-2 levels in proliferative DR patients were significantly higher than those in non-proliferative DR patients (2.83 vs 1.96 ng / ml, P <0.01), while those in non-proliferative DR patients were significantly higher than those in patients without DR (1.96 vs 1.08 ng / ml, P <0.05). The level of Ang-2 was positively correlated with hsC-RP (r = 0.63, P <0.01) and UAlb (r = 0.29, P <0.05). Conclusions The serum level of Ang-2 in T2DM patients is positively correlated with the carotid artery intima-media thickness of hsC-RP, UAlb and DR. Serum Ang-2 level can be used as an index to evaluate the renal and retinal microangiopathy in patients with T2DM.