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作者采用体内和体外试验研究了抗疟药物氯喹和伯喹对大鼠肝微粒体的药物代谢的影响。结果表明,接受一次剂量伯喹的大鼠可增加由戊巴比妥所产生的睡眠时间,其作用程度与剂量有关,也可延长氯苯(口恶)唑胺(zoxazolamine)的麻痹时间,但是,氯喹对于这两种作用却无影响。氯喹和伯喹都可引起安替比林在药物动力学上明显的改变,伯喹可延长安替比林的半衰期,减少其清除率,对分布体积变化的影响较少。氯喹对前两个
The authors investigated the effects of antimalarial drugs chloroquine and primaquine on drug metabolism in rat liver microsomes in vitro and in vivo. The results showed that rats receiving a single dose of primaquine increased the sleep time produced by pentobarbital, which was dose-dependent and prolonged the paraoxon time of zoxazolamine, but Chloroquine has no effect on these two effects. Chloroquine and primaquine can cause significant changes in the pharmacokinetics of antipyrine, and primaquine prolongs the half-life of antipyrine, reducing its clearance rate, with less impact on changes in volume distribution. Chloroquine on the first two