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目的探讨细胞型FLICE样抑制蛋白(cellular FLICE-like inhibitory protein,c FLIP)、T-box转录因子(T-box transcription factors,TBX2)mRNA在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达及意义。方法采用逆转录多聚酶链反应(RT-PCR)检测了口腔颌面部鳞癌(OSCC)、癌旁不典型增生(DOM)及正常组织(NOM)中c FLIP、TBX2mRNA表达情况。结果 OSCC中c FLIP、TBX2 mRNA的表达明显高于DOM及NOM。c FLIP及TBX2 mRNA的表达水平与患者的年龄、性别之间的差异无统计学意义(P>0.05)。结论c FLIP、TBX2 mRNA在OSCC中的表达水平较高,两者可能在OSCC的发生、发展及转移中发挥重要的作用。
Objective To investigate the expression of c-FLIP and t-box transcription factors (TBX2) mRNA in oral squamous cell carcinoma (OSCC) The expression and significance. Methods The expressions of c FLIP and TBX2 mRNA in oral and maxillofacial squamous cell carcinoma (OSCC), paraneoplastic atypical hyperplasia (DOM) and normal tissue (NOM) were detected by reverse transcription polymerase chain reaction (RT-PCR) Results The expression of cFLIP and TBX2 mRNA in OSCC was significantly higher than that in DOM and NOM. There was no significant difference in the expression levels of FLIP and TBX2 mRNA between the two groups (P> 0.05). Conclusion c FLIP and TBX2 mRNA are highly expressed in OSCC, both of which may play an important role in the occurrence, development and metastasis of OSCC.