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目的观测不同分组宫颈癌组织中瘦素及其受体的表达。方法宫颈癌患者依照病理分为A组(正常宫颈组织)20例;B组(无周围淋巴结侵润的宫颈癌组织)23例;C组(无远位转移但有淋巴结周围淋巴结转移的宫颈癌组织)19例及D组(有远位转移的宫颈癌组织)18例。采用免疫组化S-P方法检测不同分组宫颈癌组织中的瘦素及瘦素受体的表达,用光密度值对其进行测定。结果瘦素表达:A组175.45±14.07,B组146.93±12.31,C组125.12±17.05,D组103.23±15.09。组间比较差异均有统计学意义(P<0.05)。瘦素受体表达:A组169.56±11.78,B组143.93±10.56,C组124.07±14.87,D组101.45±19.34。各组间比较除B组与C组比较差异无统计学意义(P>0.05),其余各组比较差异均有统计学意义(P<0.05)。结论瘦素及其受体在不同分组组织中的表达依次升高,提示瘦素及其受体促进宫颈癌的转移、复发。
Objective To observe the expression of leptin and its receptor in different groups of cervical cancer. Methods Cervical cancer patients were divided into group A (normal cervical tissue) 20 cases according to pathology; group B (cervical cancer tissue without surrounding lymph node invasion) 23 cases; group C (cervical carcinoma without distant metastasis but lymph node metastasis 19 cases and D group (with distant metastasis of cervical cancer tissue) 18 cases. Immunohistochemical S-P method was used to detect the expression of leptin and leptin receptors in different groups of cervical cancer tissues, and their optical density was measured. Results The expression of leptin in group A was 175.45 ± 14.07, in group B 146.93 ± 12.31, in group C 125.12 ± 17.05 and in group D 103.23 ± 15.09. The differences between the two groups were statistically significant (P <0.05). Leptin receptor expression: A group 169.56 ± 11.78, B group 143.93 ± 10.56, C group 124.07 ± 14.87, D group 101.45 ± 19.34. There was no significant difference between the two groups except B group and C group (P> 0.05). The difference between the other groups was statistically significant (P <0.05). Conclusion The expression of leptin and its receptor in different groups of tissues in turn increased, suggesting that leptin and its receptor promote the transfer of cervical cancer recurrence.