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一名28岁妇女因闭经及进行性多毛症2年而就医。病人12岁月经初潮,此后经期不规则。23岁时服避孕药,随后按时行经,血量逐减。4年后停服避孕药,随之出现闭经,面部,躯体毛发进行性增加。体检显示明显的面部及乳晕周围毛发增多伴有粗糙的阴毛以男性方式向脐部蔓延,并有阴蒂肥大。实验室检查血浆睾丸酮及DHEA升高,且不受地塞米松抑制。静脉插管显示来自左肾上腺和卵巢静脉的睾丸酮浓度增高,而右侧则是正常水平。
A 28-year-old woman sought medical treatment for amenorrhea and hirsutism for 2 years. The patient’s 12-year-old menarche and irregular menstrual period thereafter. When she was 23 years old, she used contraceptives, and then she passed on time and her blood volume decreased. After 4 years, she stopped taking the contraceptives, followed by amenorrhea and progressive facial and body hair growth. The physical examination showed that the facial hair around the face and the area around the areola increased with coarse pubic hair and spread to the umbilicus in a male manner and had clitoral hypertrophy. Laboratory tests of plasma testosterone and elevated DHEA were not inhibited by dexamethasone. Venous cannulation shows increased testosterone concentrations from the left adrenal and ovarian veins, while the right side is normal.