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干扰素(IFN)是第一个在七十年代早期被试用于临床的细胞因子。在治疗恶性疾病方面,最突出的例子是用天然和重组IFN-α治疗毛细胞性白血病(HCL),有效率(即完全或部份缓解)高达80～90％,且毒性不至太大。有趣的是用IFN代南常规的脾切除疗效更好。且在无毒性作用的小剂量治疗时,也可达到缓解HCL的作用。另一些对IFN和化疗有同样效果的恶性疾病包括转移性恶性黑色
Interferon (IFN) was the first cytokine to be clinically tested in the early seventies. In the treatment of malignant diseases, the most prominent example is the treatment of hairy cell leukemia (HCL) with natural and recombinant IFN-α, effective (ie complete or partial remission) as high as 80 to 90%, and not too toxic. It is interesting to use IFN on behalf of South conventional splenectomy curative effect is better. And in the small dose of non-toxic effects of treatment, can also be achieved to alleviate the role of HCL. Other malignancies that have the same effect on IFN and chemotherapy include metastatic malignant colorectal cancer