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目的:观察生化汤联合米索前列醇片预防产后出血的临床效果。方法:纳入在本院分娩的120例产妇进行研究,按随机双盲法分为治疗组与对照组,每组60例。治疗组给予生化汤联合米索前列醇片治疗,对照组仅给予米索前列醇片治疗。治疗后评估2组治疗总有效率,统计出血量,观察患者小腹疼痛、出血量及血色的改善情况。结果:治疗组总有效率93.33%,对照组总有效率75.00%,2组比较,差异有统计学意义(P<0.01)。治疗组产后2 h和产后24 h的出血量均少于对照组,差异均有统计学意义(P<0.05)。治疗后,2组小腹疼痛、出血量、血色积分均较治疗前降低,差异均有统计学意义(P<0.05);观察组3项中医症状积分均低于对照组,差异均有统计学意义(P<0.05)。结论:生化汤联合米索前列醇片预防产后出血,效果优于单纯使用米索前列醇片,可进一步减少产后出血量和降低疼痛感。
Objective: To observe the clinical effect of Shenghua Decoction combined with misoprostol in preventing postpartum hemorrhage. Methods: A total of 120 maternal births were enrolled in this study. The patients were divided into treatment group and control group by randomized double-blind method, with 60 cases in each group. The treatment group received biochemical soup combined with misoprostol tablets, while the control group received only misoprostol tablets. After treatment, the total effective rate of the two groups was evaluated, the amount of bleeding was calculated and the patients’ abdominal pain, blood loss and the improvement of the hemochromatosis were observed. Results: The total effective rate was 93.33% in the treatment group and 75.00% in the control group. There was significant difference between the two groups (P <0.01). The amount of bleeding in the treatment group 2 h postpartum and 24 h postpartum were less than the control group, the difference was statistically significant (P <0.05). After treatment, the pain, blood loss and hemoglobin integral of lower abdomen in both groups were lower than those before treatment (all P <0.05), and the scores of three TCM symptoms in the observation group were lower than those in the control group (P <0.05). Conclusion: The combination of Shenghua Decoction and misoprostol in preventing postpartum hemorrhage is superior to using misoprostol alone, which can further reduce postpartum hemorrhage and reduce pain.