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目的 :比较 2种非甾类消炎药 (NSAIDs)萘丁美酮和尼美舒利治疗类风湿关节炎 (RA)的疗效和安全性。方法 :6 2例活动性RA病人分为 2组 ,萘丁美酮组 (治疗组 ) 30例 ,给予萘丁美酮 5 0 0mg ,po ,bid ;尼美舒利组 (对照组 ) 32例 ,给予尼美舒利10 0mg ,po ,bid。 2组均给药 4wk。受试前后观察临床和实验室指标的变化。结果 :萘丁美酮组总有效率为 87% ,尼美舒利组总有效率为 83% ,P >0 .0 5。与萘丁美酮治疗有关的不良反应包括 :恶心、胃烧灼感、反酸和嗜睡各 1例 ,不良反应率13% ;尼美舒利组不良反应率为 19% ,P >0 .0 5。结论 :萘丁美酮对RA的疗效和不良反应的发生率均与尼美舒利相似 ,是一种较为有效、安全且服用方便的NSAIDs。
Objective: To compare the efficacy and safety of two nonsteroidal anti-inflammatory drugs (NSAIDs), nabumetone and nimesulide in the treatment of rheumatoid arthritis (RA). Methods: Sixty-two patients with active RA were divided into two groups, nabumetone group (treatment group) 30 cases, nabumetone 500 mg, po, bid; nimesulide group (control group), 32 cases , Given nimesulide 10 0mg, po, bid. 2 groups were given 4wk. Observed before and after the test changes in clinical and laboratory indicators. Results: The total effective rate of nabumetone group was 87%, while the total effective rate of nimesulide group was 83%, P> 0.05. Adverse reactions associated with nabumetone treatment included nausea, a burning sensation in the stomach, one case of acid reflux and lethargy, and a 13% rate of adverse reactions, respectively. The rate of adverse reactions in the nimesulide group was 19%, P> 0.05 . Conclusion: The efficacy and adverse reactions of nabumetone to RA are similar to those of nimesulide, and they are more effective, safe and convenient to take NSAIDs.