我院于1973年应用免疫抑制药物环磷酰胺治疗流行性出血热 18例,其中对 7例作了免疫学观察(已在中华内科杂志1979年,1期发表),取得良好的效果,并发现病人的临床表现与免疫学变化有关。本文在原来的基础上增加了免疫球蛋白IgM和总补体、补体_3等测定、进一步观察了本病的免疫学动态变化与治疗效果的关系,以及免疫反应和疾病严 In our hospital in 1973, the immunosuppressive drug cyclophosphamide in the treatment of epidemic hemorrhagic fever in 18 cases, of which 7 cases were immunological observation (in the Chinese Internal Medicine, 1979, 1 published), achieved good results and found The patient’s clinical manifestations and immunological changes. In this paper, based on the original increased immunoglobulin IgM and total complement, complement _3 determination, further observation of the disease, the dynamic changes in the relationship between the immunotherapy and treatment, as well as the immune response and disease severity