Objective:To perform a systematic review of the scientific literature to identify risk factors associated with hepatitis B viruses(HBV) infection among blood donors.Methods:The literature search was carried out on Pub Med and Scopus databases using the keywords “risk factors” “HBV infection” and “blood donors”.No date or language restrictions were applied to the search.This literature review was completed in March2014.The selection process and the reporting of the review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement.The Newcastle Ottawa scale was using to evaluate the quality of each single primary study.Results:Out of 172 records resulted in the search,5 papers were included in the final analysis because they are within acceptance criteria.Two of the selected studies were cross-sectional and three of them were case-control studies.Significant association resulted with some demographic and behavioral risk factors,such as marital status,dental treatment/procedure history,no stable relationship or multiple partners and family history of HBV infection.Conclusions:The systematic review performed encourages to conduct further research among blood donors in order to fully understand risk factors among donors in more extensive thus to provide valuable information about surveillance. Objective: To perform a systematic review of the scientific literature to identify risk factors associated with hepatitis B viruses (HBV) infection among blood donors. Methods: The literature search was carried out on Pub Med and Scopus databases using the keywords “risk factors ”HBV infection“ and ”blood donors". No date or language restrictions were applied to the search. This literature review was completed in March 2014. The selection process and the reporting of the review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes Statement. The Newcastle Ottawa scale was using to evaluate the quality of each single primary study. Results: Out of 172 records resulted in the search, 5 papers were included in the final analysis because they are within acceptance criteria.Two of the selected studies were cross-sectional and three of them were case-control studies. Significant association resulted with some demographic and behavioral risk factors, such as marital status, dental treatment / procedure history, no stable relationship or multiple partners and family history of HBV infection. Conclusions: The systematic review conducted encourages to conduct further research among blood donors in order to fully understand risk factors among donors in more extensive thus to provide valuable information about surveillance.