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目的:研究塞隆风湿酒预防和治疗佐剂性关节炎、血液流变学的药效作用。方法:预防和治疗关节炎实验采用对Freund’s完全佐剂引发的大鼠原发性关节炎法;血液流变学实验采用测定大鼠凝血时间、不同切变率下全血黏度及红细胞聚集指数。结果:塞隆风湿酒能明显抑制注射Freund’s完全佐剂引起的大鼠局部早期炎症,能使大鼠不同切变率下全血黏度和红细胞聚集指数明显降低,从而改变血液流变性。结论:塞隆风湿酒有较强的预防和治疗Freund’s完全佐剂关节炎的作用,能降低血液黏度改变血液流变学指标,促进血液循环等功能。
OBJECTIVE: To study the pharmacodynamic effects of saronin in the prevention and treatment of adjuvant arthritis and hemorrheology. Methods: Arthritis was induced by Freund’s adjuvant in primary prevention and treatment of arthritis. The hemorrheology was used to determine the clotting time, the whole blood viscosity and erythrocyte aggregation index at different shear rates. RESULTS: The sargassum wine could obviously inhibit the local early inflammation induced by Freund’s complete adjuvant injection, and could significantly reduce the whole blood viscosity and erythrocyte aggregation index at different shear rates and thus change the blood rheology. Conclusion: Thearon rheumatism wine has strong prevention and treatment of Freund’s complete adjuvant arthritis, can reduce blood viscosity changes in blood rheology indicators, promote blood circulation and other functions.