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目的:研究益肾降浊方对慢性肾炎患者钙磷代谢及甲状腺激素代谢紊乱的影响机制。方法:选取我院2014年12月至2016年12月慢性肾炎患者104例,按入院顺序编号,采取随机数表法将患者分为观察组与对照组两组,每组52例,给予对照组常规西药治疗,观察组在对照组治疗基础上联合益肾降浊方治疗,比较两组临床疗效以及治疗前后肾功能、钙磷代谢、甲状腺激素代谢指标水平变化情况。结果:观察组患者临床治疗总有效率为90.38%较对照组67.31%显著较高(P<0.05);治疗后观察组血清肌酐(Scr)、血尿素氮(BUN)水平较对照组显著较低,肌酐清除率(Ccr)水平较对照组显著较高(P<0.05);观察组血磷、钙磷乘积水平较对照组显著较低,观察组血钙水平较对照组显著较高(P<0.05);观察组三碘甲状腺原氨酸(T_3)、总甲状腺素(T_4)水平较对照组显著较高,促甲状腺素(TSH)水平较对照组显著较低(P<0.05)。结论:益肾降浊方联合常规西药治疗能有效改善慢性肾炎患者临床症状,调节钙磷代谢及甲状腺激素紊乱状态,改善肾功能,安全可靠,值得临床应用推广。
Objective: To study the mechanism of Yishen Jiangzhuo decoction on the metabolism of calcium and phosphorus and thyroid hormone metabolism in patients with chronic nephritis. Methods: A total of 104 patients with chronic nephritis from December 2014 to December 2016 in our hospital were selected and numbered according to admission order. The patients were divided into observation group and control group by random number table method. Each group was given 52 cases of control group The conventional western medicine was used in the observation group. The observation group was treated with Yishen Jiangzhuo decoction on the basis of the control group. The clinical efficacy, the changes of renal function, calcium and phosphorus metabolism and thyroid hormone metabolism were compared between the two groups. Results: The total effective rate of clinical observation was 90.38% in observation group and 67.31% in control group (P <0.05). After treatment, the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) in observation group were significantly lower than those in control group , Creatinine clearance rate (Ccr) was significantly higher than that of the control group (P <0.05). The levels of serum phosphorus and calcium and phosphorus in the observation group were significantly lower than those in the control group, and the serum calcium level in the observation group was significantly higher than that in the control group (P < 0.05). The levels of triiodothyronine (T_3) and total thyroxine (T_4) in the observation group were significantly higher than those in the control group. The levels of thyroxine (TSH) in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Yishen Jiangzhuo combined with conventional western medicine can effectively improve clinical symptoms, regulate calcium and phosphorus metabolism and thyroid hormone disorders, improve renal function, be safe and reliable, and worthy of clinical application.