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目的：：分析缺血性脑卒中患者临床分型各亚型同型半胱氨酸含量,探讨同型半胱氨酸检测在其临床早期分型中的应用价值。方法：依据牛津郡社区卒中计划( OCSP)分型法将527例缺血性脑卒中患者分为四型：完全前循环梗死(TACI)；部分前循环梗死(PACI)；后循环梗死(POCI)；腔隙性梗死(LACI),利用荧光偏振免疫分析法检测各亚型及对照组(230例)同型半胱氨酸含量,并比较其差异。结果：各亚型同型半胱氨酸含量：30.3±6.3(TACI),21.2±3.4(PACI),16.1±2.7(POCI),12.1±2.7(LACI)与对照组(7.2±3.1)相比有显著性差异(P<0.01),各亚型间同型半胱氨酸含量差异有统计学意义(P<0.05)。结论：同型半胱氨酸检测可为缺血性脑卒中患者进行准确OCSP分型提供客观依据。“,”OBJECTIVE: To investigate the difference of plasma homocysteinemia ( Hcy) concentration in every subtype of OCSP classification in the patiants with cerebral ischemic stroke ( CIS) . METHOD: Plasma Hcy concentration was measured using fluores-cence polarization immunoassay ( FPLA ) and the difference of plasma Hcy concentration in OCSP classification was compared. RE-SULTS: Plasma Hcy concentration of different subtype group (TACI: 30. 3 ± 6. 3, PACI: 21. 2 ± 3. 4, POCI: 16. 1 ± 2. 7, LACI:12.1±2.7)wassignificantlyhigherthanthatinthecontrolgroup (7.2±3.1) (P<0.01); Thereweresignificanddifferencesin plasma Hcy concentration in different subtype groups (P<0. 05). CONCLUSION: Plasma Hcy concentration can provide the valua-ble information about OCSP classification in the patients with CIS.