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以每组4只10～20周龄的雄性小鼠(其中2只行2/3肝切除术)分别吸入接触浓度为104、387、591及922 ppm的苯乙烯,每天6小时共4天。另有2组小鼠在922 ppm浓度下分别接触1或2天。末次接触结束后立即开始BrdU掺入。最后检查同时收获的骨髓细胞、肺巨噬细胞和再生肝细胞的连续100个分裂中期相中第二次分裂细胞数及30个分裂中期相细胞的姊妹染色单体交换(SCE)数。实验重复进行两
Four male mice of 10 to 20 weeks of age (2 of them undergoing 2/3 hepatectomy) were exposed to 104, 375, 591 and 922 ppm of styrene, respectively, for 4 days a day for 4 days. Another two groups of mice were exposed to 922 ppm for 1 or 2 days respectively. BrdU incorporation immediately after the last contact. Finally, the number of secondly dividing cells and the number of sister chromatid exchange (SCE) of 30 meristematic metaphase cells of simultaneously harvested bone marrow cells, lung macrophages and regenerating hepatocytes were examined. Experiment repeated two