目的:探讨血1，5-脱水葡萄糖醇（1，5-AG）、糖化白蛋白（GA）和GA/糖化血红蛋白（HbAn 1c）比值用于暴发性1型糖尿病（FT1DM）和经典1型糖尿病（T1ADM）早期鉴别诊断的价值。n 方法:收集2007年1月至2018年7月上海交通大学附属第六人民医院20例FT1DM患者及47例HbAn 1c3.187，灵敏度为70.0%，特异度为76.6%，AUC为0.769，优于单用1，5-AG或GA。n 结论:GA/HbAn 1c比值在早期识别FT1DM方面，优于单用1，5-AG或GA。n “,”Objective:The aim of the current study is to investigate whether 1, 5-anhydroglucitol (1, 5-AG), glycated albumin (GA) and GA to glycated hemoglobin An 1c (HbAn 1c) ratio can be used for early identify fulminant type 1 diabetes mellitus (FT1DM) and type 1A diabetes mellitus (T1ADM).n Methods:From January 2007 to July 2018, 20 FT1DM patients and 47 newly diagnosed T1ADM patients (age and sex matched, HbAn 1c <8.7%) admitted to the Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital were included in this study. Then, the serum 1, 5-AG, GA, and HbA n 1c of these patients were measured for analysis. The 1, 5-AG, GA and GA/HbAn 1c ratio between FT1DM and T1ADM patients were compared by the n t test and Mann-Whitney n U test. The receiver operating characteristic (ROC) curve was used to evaluate the efficacy of those indicators in identifying FT1DM and T1ADM with HbAn 1c 0.05). However, the GA/HbAn 1c ratio in FT1DM patients increased significantly than those in T1ADM patients (n P=0.001). The optimal cut-off points for 1, 5-AG and GA identifing FT1DM and T1ADM were 6.2 μg/ml and 17.9%, with their sensitivity up to 95.0% and 90.0% respectively, while the specificity was only 31.9% and 34.0%, and the area under the curve (AUC) was 0.597 and 0.601, respectively. No difference was found in screening efficacy (n P=0.972). As for GA/HbAn 1c ratio, the optimal cut-off point was 3.187, with its sensitivity, specificity and AUC of 70.0%, 76.6%, and 0.769, respectively. Therefore, GA/HbAn 1c was clearly superior to 1, 5-AG or GA alone.n Conclusion:GA/HbAn 1c ratio is a better indicator for early identification of FT1DM than 1, 5-AG or GA.n