阴道原发性恶性黑色素瘤少见,本院收治二例,报告如下:例1.患者66岁,绝经18年,阴道点滴状流血伴分泌物增多3个月,1986年10月入院。妇检;外阴轻度萎缩,阴道上段前壁粘膜有一灰褐色肿物,4×3cm,触之出血,周围有3个粟粒状黑色小结节及血性分泌物,宫颈光滑。其他部位无异常。肿物活检:镜下见瘤细胞呈圆形或多边形,胞浆含黑色素,核大而圆,有明显核仁及核分裂像。病理诊断:阴道恶性黑色素瘤,上皮细胞型。确诊后即行根治术,切除组织病理检查:见肿瘤侵及阴道浆膜层及宫颈。术后化疗。5个月后因肿瘤广泛转移死亡。例2.患者80岁,自觉阴道有异物3年,白带 Vaginal primary malignant melanoma rare, admitted to our hospital in two cases, the report is as follows: Cases 1. 66-year-old man, 18 years of menopause, vaginal drip with discharge increased 3 months, admitted in October 1986. Maternal seizures; vulvar mild atrophy, vaginal anterior wall mucosa with a gray-brown tumor, 4 × 3cm, touch the bleeding, surrounded by 3 small black nodules and bloody discharge, cervical smooth. No abnormalities in other parts. Tumor biopsy: Microscopically see tumor cells were round or polygonal, cytoplasmic melanin, nuclear large and round, with obvious nucleoli and mitotic image. Pathological diagnosis: vaginal malignant melanoma, epithelial cell type. Radical surgery after diagnosis, removal of histopathological examination: see the tumor invasion and vaginal serosa and cervix. Postoperative chemotherapy. After 5 months due to extensive tumor metastasis. Example 2 patients 80 years old, vaginal foreign body 3 years, vaginal discharge