Barrett食管发生腺癌的危险增高。其上皮不典型增生是癌变的前驱,但以此作为预测腺癌发生的标志尚无定论。为此作者对经组织学证实为Barrett食管的81例患者进行定期内镜活检及随访(平均为3.6年)。23例(28%)患者于随访期间检出上皮不典型增生。首次检出并持续为高度不典型增生2例患者在2.6～4.5年没发生腺癌,当时尚无肉眼可见改变。1例 Barrett esophageal adenocarcinoma of the increased risk. The epithelial dysplasia is a precursor to carcinogenesis, but as a marker of adenocarcinoma is not yet conclusive. For this reason, the authors performed regular endoscopic biopsy and follow-up (mean, 3.6 years) of 81 patients histologically confirmed as Barrett’s esophagus. Twenty-three patients (28%) had epithelial dysplasia during follow-up. The first detected and continued as a high degree of atypical hyperplasia in 2 patients did not occur in 2.6 to 4.5 years of adenocarcinoma, no visible change at that time. 1 case