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哺乳动物Hedgehog基因家族包括3个成员:Sonic hedgehog(SHH)、Desert hedgehog(DHH)和Indian hedgehog(IHH)。SHH信号通路主要由分泌型信号糖蛋白SHH配体、跨膜蛋白受体PTCH和另一跨膜蛋白SMO的复合物,以及3种GLI蛋白的下游转录因子GLI1、GLI2、GLI3组成。作为最经典的信号通路之一,SHH信号通路在胚胎发生、发育和组织更新等过程中发挥至关重要作用。GLI1是该通路中最重要转录因子之一,其异常活化与纤维化修复、肿瘤的发生发展与侵袭转移、肿瘤耐药和预后等密切相关。本文就GLI1与肿瘤发生与侵袭转移作用机制进行综述。
The mammalian Hedgehog gene family includes three members: Sonic hedgehog (SHH), Desert hedgehog (DHH), and Indian hedgehog (IHH). The SHH signaling pathway consists of a complex of the secretory signaling glycoprotein SHH ligand, the transmembrane protein receptor PTCH and another transmembrane protein SMO, and the downstream transcriptional factors GLI1, GLI2 and GLI3 of the three GLI proteins. As one of the most classical signaling pathways, the SHH signaling pathway plays a crucial role in embryogenesis, development and tissue regeneration. GLI1 is one of the most important transcription factors in this pathway. Abnormal activation of GLI1 is associated with fibrogenesis, tumorigenesis, invasion and metastasis, tumor resistance and prognosis. This review summarizes the mechanism of GLI1 in tumorigenesis and invasion and metastasis.