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蛛网膜出血(SAH)后的脑血管痉挛的病理生理学尚未十分清楚。已知5-羟色胺(5-HT)对脑动脉有强力的收缩作用。有些学者认为该物质是晚发性血管痉挛的原因。而组织胺能使血管扩张,可能对血管有保护作用。肥大细胞是人体内产生组织胺的主要场所,其胞浆颗粒可能还含有5-HT。为此,作者将12例病人(6例死于动脉瘤破裂,6例死于胸腹部创伤)的脑底动脉环,在死后6小时内取出,用特殊固定液固定24小时,冷冻切片,以0.01%甲苯胺蓝染色,在光学显微镜下对每一视野中的肥大细胞进行计数,并求出其平均数。结果对照组的6例病人脑动脉壁中找不到肥大细胞,而6例死于动脉瘤破裂的病人的脑动脉壁肌层
The pathophysiology of cerebral vasospasm after arachnoid hemorrhage (SAH) is not well understood. Serotonin (5-HT) is known to have a potent contractile effect on the cerebral arteries. Some scholars believe that the substance is the cause of late-onset vasospasm. Histamine can make blood vessels dilate, may have a protective effect on blood vessels. Mast cells are the main sites of histamine production in humans, and their cytoplasmic granules may contain 5-HT. To this end, the author of 12 patients (6 patients died of aneurysm rupture, 6 patients died of thoracoabdominal trauma) of the cerebral artery rings, removed within 6 hours after death, fixed with special fixative for 24 hours, frozen sections, Mice were stained with toluidine blue at 0.01%, and mast cells in each field were counted under an optical microscope, and the average number thereof was calculated. Results In the control group, no mast cells could be found in 6 patients’ cerebral arteries, whereas 6 patients died of aneurysm rupture