老年多发病几乎都与机体的免疫功能状态有牵连,因此对免疫衰老的主要表现及其发生机理的研究是防治老年病的关键。现仅就近几年研究的免疫衰老的主要特点及其发生的可能机理简要综述如下: 衰老对巨噬细胞(Mφ)功能的影响Mφ在体液免疫和细胞免疫反应的诱导、调节和效应上起着重要作用。不少文献对衰老过程中Mφ的功能变化进行了研究,曾指出Mφ功能不因年老而降低。例如Mφ体外吞噬活性、降解异物能力及溶酶体酶含量均不因年老而减退。又曾证明老龄鼠Mφ起动 Almost all of the elderly are associated with the immune status of the body, so the study of the main manifestations of immune senescence and its pathogenesis is the key to preventing and treating geriatric diseases. In recent years, the main features of immune senescence and its possible mechanism are summarized as follows: The effect of aging on the function of macrophages (Mφ) Mφ plays an important role in inducing, regulating and effecting humoral and cellular immune responses Important role. Many literatures have studied the functional changes of Mφ during aging, and have pointed out that Mφ function does not decrease due to aging. For example, Mφ phagocytic activity in vitro, the ability to degrade foreign bodies and lysosomal enzyme levels are not due to age and decline. It has also been shown that old mice start Mφ