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通过原代培养大鼠肝细胞以CCl_4诱导肝损害体外试验,研究了从鸡骨草(Abrus cantoniensis)全草分离的三萜皂甙大豆皂甙Ⅰ(SⅠ)和槐花皂甙Ⅲ(KⅢ)的抗肝毒活性,并与阳性对照药甘草甜素进行比较,观察了对ALT和AST的影响。
Liver damage induced by CCl_4 in primary cultured rat hepatocytes was tested in vitro to study the anti-hepatic activity of triterpenoid saponin soyasaponin I (SI) and saponin III (KIII) isolated from whole plant of Abrus cantoniensis. The activity was compared with that of the positive control drug glycyrrhizin, and the effects on ALT and AST were observed.