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本文报道四例长期接受酰氨咪嗪(Carbamazepine)治疗的癫痫患儿,因感染而接受红霉素治疗后出现酰氨咪嗪中毒的临床表现和实验数据。例一、7岁男孩,生后18月患癫痫至今,长期接受酰氨咪嗪等药物治疗,酰氨咪嗪的剂量为400mg一日二次,定期血浓监测维持在7～12μg/ml。二次因感染而使用红霉素后出现共济失调,酩醉状,酰氨咪嗪血浓升至16、19μg/ml,停用红霉素后症状消失,酰氨咪嗪血药浓度下降。例二、8岁女孩,患癫痫史7年,酰氨咪嗪治疗,400mg一日三次。某次轻度感染,以红霉素200mg一日三次治疗三天后,出现共济失调、晕眩、呕吐、血清酰氨咪嗪浓度
This article reports the clinical and experimental data of four patients with epilepsy treated with Carbamazepine for a long time after receiving erythromycin for infection. For example, a 7-year-old boy, born with epilepsy in 18 months after his death, has been receiving amilizine and other drugs for a long time. The dose of amilizine is 400 mg twice a day. Periodic blood concentration monitoring is maintained at 7-12 μg / ml. Secondary infection with erythromycin after ataxia, 酩 drunk, amiloride blood concentration rose to 16,19μg / ml, after the withdrawal of erythromycin symptoms disappeared, amipramine plasma concentration decreased . Case 2, 8-year-old girl, suffering from epilepsy history 7 years, amilizine treatment, 400mg three times a day. A mild infection with erythromycin 200mg three days a day for three days, ataxia, dizziness, vomiting, serum amidrazin concentration