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本文研究局部解充血剂——氯化羟间唑啉(oxymetazoline chloride)对正常和急性鼻炎早期鼻粘膜血流的作用。方法:测定18名健康者鼻腔用药前后的鼻粘膜血流;其中8名在其早期急性鼻炎(发病第1～2天)时在用药前后测定;又选择18名中的5名在用不同浓度(0.01～3mg/ml)药物后测定。全部实验者前鼻镜检正常,实验期间未用任何药物,15分钟后将浓度为0.5mg/ml的0.1ml药液(临床推荐剂量)滴于下鼻甲处,仰卧2分钟后测定用药后的鼻血流。早期急性鼻炎前鼻镜检见粘膜红肿,有粘液样或粘脓性分泌物。采用~(133)Xe(同位素氙)冲洗法,依据冲洗曲线最初5分钟出现的斜率计算血流值。另选3名健康者用0.1ml Nezeril安慰剂作为对照。全部数据经统计学处理。
This article investigates the effect of a topical decongestant, oxymetazoline chloride, on nasal mucosal blood flow in normal and acute rhinitis. Methods: Nasal mucosal blood flow was measured before and after nasal administration in 18 healthy subjects. Eight of them were determined before and after the treatment of their early acute rhinitis (onset days 1 ~ 2). Five of the 18 infants were selected at different concentrations (0.01 ~ 3mg / ml) drugs after the test. All subjects before the nasal examination was normal, without any medication during the experiment, after 15 minutes at a concentration of 0.5mg / ml of 0.1ml liquid (clinical recommended dose) drops in the inferior turbinate at supine for 2 minutes after the determination of the drug Nose blood flow. Early acute rhinitis nasal mucosa before the redness, mucoid or mucopurulent secretions. Blood flow was calculated from the slope of the first 5 minutes of the flushing curve using the ~ (133) Xe (isotope xenon) flushing method. Another three healthy volunteers with 0.1ml Nezeril placebo as a control. All data are statistically processed.