食管癌高发地区环境病因的研究表明亚硝胺化合物可能是人类食管癌发病因素之一。为了探讨食管癌病因预防的措施,除了降低饮用水等亚硝胺类的含量和致癌活性作用外,阻断进入体内的或体内合成的亚硝胺类对细胞的毒性也是一个重要环节。 阻断亚硝胺类的毒性研究,以往以整体动物实验肿瘤为主要对象,而近年来,研究正迅速地转向细胞水平。建立维生素C阻断或亚阻断亚硝基胍(N-Metyl-N’ -ntro-N-nitrosoguanidine,MNNG)毒性的实验细胞学研究模型,目的在于筛选阻断致癌物毒性的非细胞毒性药物,并为食管癌高发区的病 Studies on the etiological factors of esophageal cancer in high incidence areas show that nitrosamines compounds may be one of the risk factors of human esophageal cancer. In order to explore the cause of esophageal cancer prevention measures, in addition to reducing the content of nitrosamines such as drinking water and carcinogenic activity, blocking into the body or in vivo synthesis of nitrosamines on cell toxicity is also an important part. Studies that block the toxicity of nitrosamines have historically focused on whole-body experimental tumors, and in recent years research is rapidly turning to cellular levels. To establish an experimental cytological model of vitamin C blockade or sub-blockage of the cytotoxicity of N-Met-N-nitrosoguanidine (MNNG) with the purpose of screening non-cytotoxic drugs that block the toxicity of carcinogens , And high incidence of esophageal cancer disease