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目的探讨不同病变程度的酒精性肝病(ALD)患者血浆同型半胱氨酸(HCY)水平的差异。方法选择ALD患者200例,根据病理结果分为4个试验组:酒精性脂肪肝组85例,酒精性肝炎组68例,酒精性肝纤维化组23例,酒精性肝硬化组24例,并选取健康体检者200例作为对照组,检测标本血浆中的HCY。结果酒精性脂肪肝组、酒精性肝炎组、酒精性肝纤维化组、酒精性肝硬化组HCY值均高于对照组,差异均有统计学意义(P<0.05);酒精性脂肪肝组和酒精性肝炎组比较,差异无统计学意义(P>0.05),酒精性肝纤维化组和酒精性肝硬化组均高于酒精性脂肪肝组和酒精性肝炎组,差异均有统计学意义(P<0.05)。结论 ALD患者HCY水平的高低可反映肝功能损害程度,对ALD的诊断、治疗具有监测价值。
Objective To investigate the plasma homocysteine (HCY) levels in patients with alcoholic liver disease (ALD) with different pathological changes. Methods 200 patients with ALD were selected and divided into four groups according to the pathological results: 85 patients with alcoholic fatty liver disease, 68 patients with alcoholic hepatitis, 23 alcoholic liver fibrosis patients and 24 alcoholic cirrhosis patients. Two hundred and seventy healthy subjects were selected as the control group to detect HCY in the sample plasma. Results The values of HCY in alcoholic fatty liver group, alcoholic hepatitis group, alcoholic liver fibrosis group and alcoholic cirrhosis group were significantly higher than those in control group (P <0.05). Alcoholic fatty liver group There was no significant difference between alcoholic hepatitis group and alcoholic hepatitis group (P> 0.05). Alcoholic liver fibrosis group and alcoholic cirrhosis group were higher than alcoholic fatty liver group and alcoholic hepatitis group, the differences were statistically significant ( P <0.05). Conclusion The level of HCY in patients with ALD can reflect the degree of liver dysfunction and has the value of monitoring and diagnosis of ALD.