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目的:探讨黄芪解毒汤体外干预乳腺癌细胞基因(突变型P53及Ki-67)表达的影响,揭示本方抑制乳腺癌复发转移的作用机制。方法:采用MTT法及免疫细胞化学,观察黄芪解毒汤煎剂组、黄芪解毒汤血清组及阿霉素组在体外实验中对MCF-7乳腺癌细胞的抑制作用和对其基因表达的影响。结果:黄芪解毒汤对乳腺癌细胞增殖有抑制作用,对突变型P53及Ki-67基因表达有下调作用。结论:黄芪解毒汤能下调突变型P53及Ki-67基因阳性表达水平的作用,为黄芪解毒汤在乳腺癌术后治疗中的作用提供实验依据。
Objective: To investigate the effect of Huangqi Jiedu Decoction on the expression of breast cancer cell lines (mutant P53 and Ki-67) in vitro and to reveal its mechanism of inhibiting the recurrence and metastasis of breast cancer. Methods: MTT assay and immunocytochemistry were used to observe the effects of Huangqi Jiedu Decoction, Huangqi Jiedu Decoction and doxorubicin on MCF-7 breast cancer cells in vitro and its gene expression. Results: Huangqi Jiedu Decoction could inhibit the proliferation of breast cancer cells and down-regulate the expression of mutant P53 and Ki-67 genes. Conclusion: Astragalus and Jiedu Decoction can down-regulate the positive expression of mutant P53 and Ki-67 gene and provide experimental evidence for the role of Huangqi Jiedu Decoction in postoperative treatment of breast cancer.