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[目的]探讨细胞间黏附分子-1(ICAM-1)与肝细胞癌(HCC)的关系及其临床病理意义。[方法]收集HCC手术切除标本46例(HCC组)、癌旁组织标本33例(癌旁组),外伤性肝破裂手术切取标本5例(正常对照组),采用免疫组化SABC法染色检测各组ICAM-1的表达。[结果]正常对照组ICAM-1均呈阴性表达。HCC组I-CAM-1均呈阳性表达,总阳性率为58.7%(27/46),其中癌旁组阳性率为87.9%(29/33)(P﹤0.05)。ICAM-1表达与患者年龄、性别、AFP是否阳性无关(P﹥0.05),而与HBsAg是否阳性关系密切(P﹤0.05),与HCC病理分级、有无包膜及有无癌栓关系密切(P﹤0.05)。[结论]ICAM-1的表达可以加促HCC的发生、发展、侵袭和转移。
[Objective] To investigate the relationship between the expression of intercellular adhesion molecule-1 (ICAM-1) and hepatocellular carcinoma (HCC) and its clinicopathological significance. [Methods] Forty-six cases of HCC (HCC group), 33 cases of paracancerous tissues (paracarcinoma group) and 5 cases of traumatic rupture of liver (normal control group) were collected from patients with HCC. Immunohistochemical staining with SABC method The expression of ICAM-1 in each group. [Results] ICAM-1 was negative in normal control group. The positive rate of I-CAM-1 in HCC group was 58.7% (27/46). The positive rate of I-CAM-1 in HCC group was 87.9% (29/33) (P <0.05). The expression of ICAM-1 was not related to the age, gender and AFP (P> 0.05), but positively correlated with HBsAg (P <0.05), and was closely related to the pathological grade of HCC, P <0.05). [Conclusion] The expression of ICAM-1 can increase the occurrence, development, invasion and metastasis of HCC.