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目的:评价阿托伐他汀联合二甲双胍治疗多囊卵巢综合征的有效性和安全性。方法:选取多囊卵巢综合征(P-COS)患者54例,随机均分为两组,对照组患者采用安慰剂预治疗3个月再用二甲双胍治疗6个月,实验组患者阿托伐他汀预治疗3个月,再用二甲双胍治疗6个月两种疗法,行随机双盲对照试验对患者状况进行评估。结果:阿托伐他汀预治疗组生化指标(睾酮、SHBG、FAI、FBG、FINS、HOMA-IR、hsCRP)得到显著改善,说明阿托伐他汀联合二甲双胍治疗PCOS疗效优于单独使用二甲双胍。
Objective: To evaluate the efficacy and safety of atorvastatin combined with metformin in the treatment of polycystic ovary syndrome. Methods: Fifty-four patients with polycystic ovary syndrome (P-COS) were randomly divided into two groups. Patients in the control group were treated with placebo for 3 months and metformin for 6 months. Patients in the experimental group received atorvastatin Pretreatment for 3 months, then metformin treatment for 6 months, two kinds of therapy, a randomized double-blind controlled trial to assess the patient’s condition. Results: Atorvastatin pretreatment group of biochemical indicators (testosterone, SHBG, FAI, FBG, FINS, HOMA-IR, hsCRP) was significantly improved, indicating that atorvastatin combined with metformin in the treatment of PCOS better than using metformin alone.