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百白破-b型流感嗜血杆菌-乙型肝炎病毒(DTaP-PRP-T-HB联合疫苗是在DTaP的破伤风毒素上连接b型流感嗜血杆菌多糖Hib-PS和HB疫苗。作者选择331个健康婴儿随机分成两组,分别在2、4、6月龄以两种方式接种疫苗。第1组接种DTaP-PRP-T-HB联合疫苗;第2组同时接种DTaP、PRP-T和HB3种疫苗。经过3次接种后,第1组有121(37%)个婴儿抗Hib-PS<1.0μg/ml,其中43个婴儿在9～13个月用Hib结合疫苗(CRM197-OS)加强免疫,并在加强前和加强1个月后取血,做抗Hib-PS ELISA及亲合力分析。
Baitabu-Haemophilus influenzae type b-Hepatitis B virus (DTaP-PRP-T-HB combination vaccine is a Haemophilus influenzae type b polysaccharide Hib-PS and HB vaccine linked to DTaP tetanus toxin. 331 healthy infants were randomly divided into two groups and vaccinated at two, four and six months respectively in two ways: Group 1 received DTaP-PRP-T-HB combination vaccine; Group 2 received DTaP, PRP-T and HB3 vaccines, 121 (37%) infants in group 1 had anti-Hib-PS <1.0 μg / ml after 3 injections and 43 infants were vaccinated with the Hib conjugate (CRM197-OS) at 9 to 13 months Booster immunization and blood sampling one month before and after augmentation, anti-Hib-PS ELISA and affinity analysis.