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目的 探寻大鼠腺胃正常粘膜与异型增生和腺癌的形态定量参数指标 ,探讨大鼠实验性胃癌与人类胃癌形态变化的异同性。方法 利用HPIAS - 10 0 0型图象分析系统对大鼠腺胃正常粘膜与由MNNG诱发粘膜异型增生及腺癌进行形态定量研究。结果 大鼠腺胃粘膜与不典型增生细胞核八项形态定量指标经统计学处理比较 :其中核面积 ,核周长 ,核等效直径 ,核体积 ,核长径 ,核形状因子六项指标 (P <0 .0 1) ;核短径、核长短径比 (P >0 .0 5 )差异无显著性。大鼠腺胃异型增生与腺癌细胞核八项形态定量指标比较 ,核面积 ,核周长 ,核等效直径 ,核体积 ,核长径 ,核形状因子六项形态定量参数指标差异有高度显著性。结论 大鼠腺胃粘膜癌变与人类胃粘膜癌变有同样的形态学改变过程。
Objective To explore morphometric parameters of normal gastric mucosa, dysplasia and adenocarcinoma in rats and explore the similarities and differences of morphological changes of experimental gastric carcinoma and human gastric carcinoma in rats. Methods HPIAS - 100 0 image analysis system was used to study morphological changes of gastric mucosa in normal gastric mucosa and mucosal dysplasia and adenocarcinoma induced by MNNG. Results The quantitative and qualitative indexes of eight morphological features of glandular mucosa and atypical hyperplastic nucleus in rats were compared by statistical analysis: six indexes (nuclear area, perinucleus, equivalent diameter, nuclear volume, nuclear long axis and nuclear shape factor) <0 01). There was no significant difference in nuclear short axis and nuclear aspect ratio (P> 0.05). There was a significant difference in the quantitative parameters of the six morphological parameters of nucleus size, nuclear perimeter, nuclear equivalent diameter, nuclear volume, nuclear long axis and nuclear shape factor . Conclusions The carcinogenesis of glandular gastric mucosa in rats has the same morphological change process as the carcinogenesis of human gastric mucosa.