论文部分内容阅读
目的：探讨膀胱移行细胞癌癌基因蛋白表达与预后的关系。方法：应用免疫组织化学，检测１５０例膀胱移行细胞癌ｐ２１、ｐ１８５、ｐ５３三种蛋白表达。结果：膀胱移行细胞癌ｐ２１、ｐ１８５、ｐ５３蛋白表达阳性率分别为５９．３％、５５．３％、２９％。其中７３例膀胱移行细胞癌存在两种以上蛋白共同表达。ｐ２１、ｐ１８５蛋白表达阳性率与膀胱移行细胞癌分级呈负相关（Ｐ＜０．０５），ｐ５３蛋白表达阳性率与膀胱移行细胞癌分级呈正相关（Ｐ＜０．０１）。ｐ２１蛋白表达阳性率与预后呈负相关，ｐ５３与预后呈正相关。结论：ｐ２１、ｐ５３蛋白表达检测有助于判断膀胱癌的预后。
Objective: To investigate the relationship between oncogene protein expression and prognosis in transitional cell carcinoma of the bladder. Methods: Immunohistochemistry was used to detect the expressions of p21, p185 and p53 in 150 cases of bladder transitional cell carcinoma. Results: The positive rates of p21, p185 and p53 in bladder transitional cell carcinoma were 59.3%, 55.3% and 29% respectively. 73 cases of bladder transitional cell carcinoma there are two or more proteins co-expression. The positive rates of p21 and p185 were negatively correlated with the grade of BTCC (P <0.05). The positive rate of p53 protein was positively correlated with the grade of bladder transitional cell carcinoma (P <0.01). The positive rate of p21 protein expression was negatively correlated with prognosis, and p53 was positively correlated with prognosis. Conclusion: The detection of p21 and p53 protein may be helpful in judging the prognosis of bladder cancer.