细胞黏附分子是一类介导细胞与细胞、细胞与细胞外基质间黏附作用的膜表面糖蛋白,是参与免疫反应和炎症反应多个环节的重要成分,在同种异体移植反应中具有重要作用,如参与缺血／再灌注损伤、白细胞浸润移植物的级联反应、T淋巴细胞的活化及效应细胞与靶细胞之间的相互作用等,是器官移植干预治疗中极具吸引力的靶分子。 Cell adhesion molecule is a kind of membrane surface glycoprotein that mediates the adhesion between cells and cells, cells and extracellular matrix. It is an important component involved in many aspects of immune reaction and inflammatory reaction and plays an important role in allograft response , Such as involved in ischemia / reperfusion injury, cascade of leukocyte infiltration graft, T lymphocyte activation and the interaction between effector cells and target cells, is an attractive target for organ transplantation interventional therapy .