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目的应用同位素示踪法,研究镍在大鼠体内的药物动力学参数及镉对镍在大鼠组织内残留的影响。方法选取36只大鼠,随机分为6组,1组镍镉混合液灌胃给药后,不同时间断尾取血,另5组不同剂量镍镉混合液灌胃15d后处死,血样和各组织消化处理后测量放射性计数。结果镍的血液浓度-时间曲线符合二房室开放模型,0.53h达到吸收峰值24987.75cpm/mL,随后很快消除,清除速率常数为0.42mL/(kg·h);镉剂量为0mg/kg时,镍在所有组织中均有残留;镉剂量较低时(0.5,1,10mg/kg),几乎所有组织均未发现组织残留;当镉的剂量升高到25mg/kg,镍残留量有所回升,但仍低于单独给镍时;当镉剂量为10mg/kg时,眼球、肾脏和毛中镍残留量分别为(0.72±0.31),(0.00±0.01),(1.58±0.78)kBq,与其他组织比较,差异有统计学意义(P<0.05)。结论镉对镍在大鼠各器官内残留量影响较大,小剂量镉明显抑制镍的组织残留,剂量较大时,抑制效应有所减弱。
Objective To study the pharmacokinetic parameters of nickel in rats and the effect of cadmium on the residual nickel in rats using isotope tracer method. Methods Thirty-six rats were randomly divided into six groups. One group of nickel-cadmium mixture was administered intragastrically at different time points, and the other 5 groups were sacrificed 15 days after dosing. Tissue digestion after the measurement of radioactivity count. Results The blood concentration-time curve of nickel conformed to the two-compartment open model and reached the peak absorption value of 24987.75 cpm / mL at 0.53h. The elimination rate constant was 0.42mL / (kg · h) Nickel remained in all tissues; at low cadmium doses (0.5, 1, 10 mg / kg), no tissue residue was found in almost all tissues; when the dose of cadmium was increased to 25 mg / kg, nickel residues recovered (0.72 ± 0.31), (0.00 ± 0.01), (1.58 ± 0.78) kBq, respectively, when the cadmium dose was 10mg / kg Other organizations, the difference was statistically significant (P <0.05). Conclusion Cadmium has a significant effect on the residual amount of nickel in various organs of rats. Cadmium at a low dose significantly inhibits the residual of nickel. At higher doses, the inhibitory effect is weakened.