论文部分内容阅读
一部分癌性和结核性胸水,因未查到病理细胞学和病原细菌学的明确依据而诊断有困难,约占胸水病例的20％左右。为寻找更多的胸水辅助检诊指标,我们应用放射免疫分析法试对21例癌性和24例结核性的胸水中TXB_2和6-酮-PGF_1α含量变化作了测定,对结果及其临床意义进行了分析,现报告如下。一、材料和方法;(1)病例选择:采集的45例胸腔积液患者中24例(男15,女9例),年龄52.4±11.9岁,均为癌性胸水,有病理细胞学依据,其中肺腺癌12例,肺大细胞和小细胞癌各2例;乳腺癌3例;间皮细胞瘤和淋巴瘤各1例。21例(男12,女9,年龄27.9±11.4岁)为结核性胸膜炎,临床上均有低热、盗汗、乏力、消瘦等常见的结核病中毒症状,经过系统抗结核药物治疗后症状消失,胸水也在20～40天内吸收,经临床半年以上随访均排除其它疾病所致的胸腔积液。(2)胸水样品采集及处理:按照医疗操作护理常规要求作胸膜腔穿刺抽取胸水,以肉眼观察非血性胸水为合格,留取10ml供检测用。参照尿样品处理方法,取1ml胸水于
Some of the cancerous and tuberculous pleural effusions are difficult to diagnose because they do not have a clear basis for pathological cytology and pathogenic bacteriology, accounting for about 20% of cases of pleural effusions. In order to find more auxiliary indicators for pleural effusion, we used radioimmunoassay to determine the changes of TXB_2 and 6-keto-PGF_1α in 21 cases of cancer and 24 cases of tuberculous pleural pleural effusion. The results were of clinical significance. The analysis is as follows. First, materials and methods; (1) Case selection: Of the 45 patients with pleural effusion collected, 24 (15 males and 9 females) aged 52.4±11.9 years were cancerous pleural effusions with cytopathological basis. There were 12 cases of lung adenocarcinoma, 2 cases of lung large cell and small cell carcinoma, 3 cases of breast cancer, 1 case of mesothelioma and 1 case of lymphoma. 21 cases (12 males, 9 females, age 27.9±11.4 years) were tuberculous pleurisy. There were common symptoms of tuberculosis such as low fever, night sweats, fatigue, and weight loss. The symptoms disappeared after treatment with systemic anti-tuberculosis drugs. Within 20 to 40 days of absorption, the pleural effusion caused by other diseases was excluded after more than six months of clinical follow-up. (2) Collection and treatment of pleural effusion samples: According to the medical practice and routine nursing requirements, pleural effusions should be taken for pleural effusion, and non-bloody pleural effusions should be visually observed as qualified, and 10 ml should be taken for testing. Refer to urine sample processing method, take 1ml pleural effusion